Interferent Effect of Hydroxyurea on Continuous Glucose Monitoring

While currently available continuous glucose monitoring (CGM) systems have continually improving accuracy that has revolutionized modern diabetes care, potential medication interferences are recognized for all CGM (1). For Dexcom systems, hydroxyurea was recently as an interfering substance can falsely elevate sensor (SG) readings (2), but the data demonstrating this interference not been previously published. We report a patient with type 1 taking who experienced elevated SG values using G5 and G6 which led to recognition of interferent effect hydroxyurea. A 69-year-old woman insulin pump (Medtronic Paradigm Revel 723) real-time (initially G5, then G6) took (1,000 mg daily) treatment essential thrombocytosis. She noted that, approximately 6 h after hydroxyurea, measurements predictably markedly increased, even while fasting when time ingestion varied. In addition, management indicator (7.6%) based on 14-day average (170 mg/dL) significantly higher than concomitant glycated hemoglobin (6.3%, 45 mmol/mol), suggestive artifactual discordance. Subsequently, simultaneously wore …